Links on this page are about genetics information and MPNs.
More general MPN information is at the main MPN guidelines and articles page.
An important video presentation by Dr Jyoti Nangalia, courtesy of the MPN Education Foundation at its 2025 MPN conference, provides an excellent overview of MPN molecular biology.
This presentation and accompanying slides can be accessed HERE.
Genetics Information
- Evolution of myeloproliferative neoplasms from normal blood stem cells, MPN review series, Haematologica, April, 2025
- Life histories of myeloproliferative neoplasms inferred from phylogenies, Nature, 2022
- Characterization of myeloproliferative neoplasms based on genetics only and prognostication of transformation to blast phase, Nature, 2024
- Genetic basis and molecular profiling in myeloproliferative neoplasms, Blood, 2023
- Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement, Pathology, 2022
- Classification and Personalized Prognosis in Myeloproliferative Neoplasms, NEJM, 2018
- Prevalence and phenotypes of JAK2 V617F and calreticulin mutations in a Danish general population, Blood, 2019
- ASXL1 mutations are prognostically significant in PMF, but not MF following essential thrombocythemia or polycythemia vera, Blood Advances (letter), 2022
- Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study
- Genetics Home Reference – Your Guide to Understanding Genetic Conditions
- ET https://ghr.nlm.nih.gov/condition/essential-thrombocythemia
- PV https://ghr.nlm.nih.gov/condition/polycythemia-vera#resources
- MF https://ghr.nlm.nih.gov/condition/primary-myelofibrosis
Links to information on various genetic mutations
- JAK2 https://ghr.nlm.nih.gov/gene/JAK2
- CALR https://ghr.nlm.nih.gov/gene/CALR
- MPL https://ghr.nlm.nih.gov/gene/MPL#resources
- TET2 https://ghr.nlm.nih.gov/gene/TET2#conditions
