A review article has just been published in the journal haematologica, titled Clonal hematopoiesis and its progression to myeloid neoplasms: insights into risk, biology, and therapeutic strategies.
This is a wide ranging review article and concerns all myeloid neoplasms, not only myeloproliferative neoplasms. It explains that “Clonal hematopoiesis (CH) is common with advancing age and becomes nearly ubiquitous in middle age. Although typically asymptomatic, CH is associated with an increased risk of hematologic malignancies particularly myeloid neoplasms (MN), diverse non-malignant conditions, and all-cause mortality. Over the past decade, research has provided major insights into the origins of CH. In addition to aging, CH is promoted by environmental exposures, inherited genetic predisposition, and acquired conditions. Large-scale population and longitudinal sequencing studies have identified determinants of clonal behavior.”
Encouragingly the article goes on to discuss possible intervention approaches for consideration for clinical trials etc. The diagram below is a screenshot of figure 2 and it’s described as Summary of the intervention approaches to mitigate malignant transformation in high-risk clonal hematopoiesis and clonal cytopenia of undetermined significance.
With thanks to the journal haematologica, this fascinating review article is freely available to read in full.
